Pharmacokinetics in anaesthesia
نویسندگان
چکیده
منابع مشابه
The contribution of pharmacokinetics and pharmacodynamics to clinical anaesthesia care.
Defining dose requirement, pharmacokinetics and pharmacodynamics Clinical anaesthetists administer doses of drugs to obtain various degrees of drug effect. Some anaesthetic drug effects, such as muscle relaxation, are relatively easy to quantitate, whereas others such as anaesthetic depth are much more difficult. Anaesthetic dose requirement can be defined as the dose of drug that produces a de...
متن کاملThe effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: Pharmacokinetics.
The addition of adrenaline to solutions of etidocaine or lignocaine for extradural administration resulted in significantly lower plasma koncentrations in both the arterial blood (14% decrease for etidocaine and 43% decrease for lignocaine) and venous blood (35% and 60% decreases for etidocaine and lignocaine respectively). The nett absorption over the first 4 h after administration, measured f...
متن کاملPharmacokinetics of propofol and haemodynamic changes during induction of anaesthesia in uraemic patients.
The pharmacokinetics of an i.v. bolus of propofol 2 mg kg-1 were studied in 10 uraemic patients undergoing renal transplantation and in seven healthy controls matched for age, weight and duration of anaesthesia. Haemodynamic changes during induction of anaesthesia were recorded in the uraemic and in 10 healthy control patients. Pharmacokinetic variables were similar in uraemic and control patie...
متن کاملThe effect of hypernatraemia on ketamine anaesthesia in male rats
We studied the effects of a single ketamine injection in an experimental model of chronic hypernatraemia in rats. Three groups, each of 20 male Wistar rats were chosen for the experiment; the control group was given water and the test groups were given 1% (group 1) and 2% (group 2) NaCl solutions for two weeks. All groups were fed with the same diet, containing about 0.5% salt. Other living con...
متن کاملCaesarean in mare by Marcenac incision under local anaesthesia
A nulliparous non-descript mare was presented with a complaint of dystocia. The mare was recumbent and physical examination revealed that the animal was in shock. There was no straining and foetal forelimbs were visible outside the vulva. The foetus was dead as there was no pedal reflex. Vaginal examination revealed anterior presentation with dorso-sacral position and rigid lateral head deviati...
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ژورنال
عنوان ژورنال: Canadian Anaesthetists’ Society Journal
سال: 1984
ISSN: 0008-2856,1496-8975
DOI: 10.1007/bf03015269